SCM

[#2545] additional option for estlambda

Date:
2013-02-17 13:50
Priority:
3
State:
Open
Submitted by:
Yurii Aulchenko (yurii)
Assigned to:
Nobody (None)
Product:
None
Operating System:
None
Component:
GenABEL
Summary:
additional option for estlambda

Detailed description
Following Balding and Astle, 2010:

If I take say 95% lower distribution of chi2 from my GWAS (say chi2_95), then the lambda estimate is

Lambda <- mean(chi2_95) /k

where k is

(1/0.95)*pchisq((qchisq(0.95,df=1)),df=3) = 0.756

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