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[#2545] additional option for estlambda
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Date:
2013-02-17 13:50
Priority:
3
State:
Open
Submitted by:
Yurii Aulchenko (
yurii
)
Assigned to:
Nobody (None)
Product:
None
Operating System:
None
Component:
GenABEL
Summary:
additional option for estlambda
Detailed description
Following Balding and Astle, 2010:
If I take say 95% lower distribution of chi2 from my GWAS (say chi2_95), then the lambda estimate is
Lambda <- mean(chi2_95) /k
where k is
(1/0.95)*pchisq((qchisq(0.95,df=1)),df=3) = 0.756
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